Monday, October 8, 2012

Danish saxophonist John Tchicai dies

(AP) ? Danish saxophonist and pioneer of free jazz in Europe, John Tchicai, has died. He was 76.

Tchicai moved to New York in 1963 and co-founded The New York Contemporary Five with Archie Shepp. He later became a leading figure of the jazz avant-garde movement in Europe. He also played with John Coltrane, Milford Graves, Carla Bley and Steve Swallow.

Tchicai was born to a Danish mother and a Congolese father in Denmark. He returned to Europe in 2001 and eventually settled in southern France.

His former wife, Margriet Naber, said Monday that he had died in the hospital earlier that day. No cause of death was given but Tchicai has been in a coma since suffering a brain hemorrhage in June.

No funeral arrangements were immediately available.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-10-08-Denmark-Obit-Tchicai/id-803604336e2b4e4f86fda974bfc5555c

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Tuesday, October 2, 2012

Moscow court postpones Pussy Riot appeal

MOSCOW (AP) ? An appeal by three members of jailed rock band Pussy Riot was postponed Monday after one of them fired her lawyers in what prosecutors criticized as a delaying tactic.

The two year-sentences given in August to the three performers for hooliganism after they performed a "punk prayer" against President Vladimir Putin at Moscow's main cathedral have provoked an international outcry, and celebrities worldwide have expressed support for the trio.

Band member Yekaterina Samutsevich unexpectedly announced at the opening of Monday's hearing that she has fired her three lawyers over an unspecified disagreement.

Samutsevich said she had found another lawyer but had not yet signed a contract.

Her fellow band members said they supported Samutsevich's choice but would still retain the services of the lawyers.

The appeal was adjourned until Oct. 10. Prosecutors condemned the move as a delaying tactic.

Olga Mefodyeva, an analyst at the Center for Political Technologies, suggested the decision might have been a public relations ploy.

"It is possible that because attention to the case has weakened somewhat, they are using such events to draw that attention once again and make this issue into a subject of active discussion," Mefodyeva said.

Nadezhda Tolokonnikova, 22, Maria Alekhina, 24, and 30-year-old Samutsevich were arrested in March after dancing and high-kicking at Moscow's Christ the Savior Cathedral as they pleaded with the Virgin Mary to save Russia from Putin, who was elected to a third presidential term two weeks later.

They said during their trial in August that they were protesting the Russian Orthodox Church's support for Putin and didn't intend to offend religious believers.

The women have all been resolutely defiant during their initial court hearings, but the apparent differences over their legal strategy have led to speculation of possible fissures.

Defense lawyer Nikolai Polozov said the group had come under threats and psychological pressure from authorities.

"They threatened to take away their children," Polozov said after Monday's hearing. "They try to find weak spots from any angle. Essentially, their position is to push them apart."

The Russian Orthodox Church said Sunday the rockers would deserve mercy if they repent for their February stunt. Earlier, Prime Minister Dmitry Medvedev had said that keeping them in prison any longer would be "unproductive."

The calls reflected an apparent desire by both the government and the church to put an end to the case, which has caused international outrage.

The band members' imprisonment has come to symbolize intolerance of dissent in Putin's Russia and caused a strong international condemnation. Their cause has been taken up by celebrities and musicians, including Madonna and Paul McCartney, and protests have been held around the world.

Even some government loyalists criticized the harsh sentence, voicing concern about the church's interference in secular affairs and a growing repressive streak in the Kremlin's policies.

Dozens of supporters gathered outside the court building in solidarity with the group.

The international support for the group, however, has also fostered irritation among many Russians over what they perceive to be foreign meddling in their justice system.

A group of anti-Pussy Riot demonstrators outside the court carried inflatable female dolls in balaclavas to the court building in protest at international organizations bestowing awards on the band.

Source: http://news.yahoo.com/moscow-court-postpones-pussy-riot-appeal-082424772.html

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Boat sinks off Hong Kong after collision; 36 dead

HONG KONG (AP) ? A boat packed with revelers on a long holiday weekend collided with a ferry and sank off Hong Kong, killing at least 36 people and injuring dozens in the deadliest accident to strike the Chinese territory in years.

The boat was carrying utility company workers and their families to famed Victoria Harbour to watch a fireworks display in celebration of China's National Day and mid-autumn festival. The two vessels collided Monday night near Lamma Island off the southwestern coast of Hong Kong Island.

The government said 36 bodies had been recovered as of Tuesday morning and the search was made difficult by low visibility and obstacles on the boat. Details about the victims were not given, though local outlet RTHK reported some of the dead were children.

More than 100 people were rescued and sent to hospitals, and nine had serious or critical injuries, the government's statement said. At least one person appeared to be missing, according to government figures.

Such large-scale accidents are rare for Hong Kong, a semiautonomous enclave off mainland China that has one of Asia's most advanced infrastructures and economies with first-rate public services.

The tragedy is also the latest test for the new administration of Hong Kong's Beijing-installed chief executive, Leung Chun-ying, who rushed to the pier where rescue work was taking place.

Leung's July inauguration was greeted by protests, and opposition by students and their parents against the proposed teaching of China-influenced patriotic history forced his government to back off the plan last month.

"All of Hong Kong's emergency forces are focused here," Leung said earlier. "Wide-ranging rescue work is being carried out on in the sea, land and in the air." Leung said he didn't know what caused the collision but promised a thorough investigation.

After daybreak, the boat was half submerged with its bow pointing almost straight up. A barge was tied alongside it, apparently to stabilize the sunken boat and keep it from tipping further.

Hong Kong fire services had deployed seven boats, including one to support diving operations, and more than 200 rescue personnel, the government said. Four rescue boats and a team of divers also were dispatched from the mainland Chinese province of Guangdong just across the border, the official Xinhua News Agency reported.

"There was a boat that came in close and crashed," said Yuen Sui-see, director of operations at Power Assets Holdings Ltd., which was using the vessel to take staff on the outing. "After the crash, the other boat continued away, it didn't stop." He denied the vessel was overloaded, saying it was carrying 121 passengers and three crew but had capacity for more than 200 passengers.

Local news reports said the boat was hit by a ferry operated by the Hong Kong and Kowloon Ferry company on a regularly scheduled service. RTHK said the ferry captain was afraid to stop in case it sank, too, and returned to port safely. Local TV later showed images of the ferry, with its bow chewed up and chunks missing.

Survivors said the boat started sinking rapidly after the collision. One woman told local television that she swallowed a lot of water as she swam back to shore. Another man said he didn't know where his children were. Neither gave their names.

Lamma is the third-biggest island in Hong Kong and near one of the coastal Chinese city's busiest shipping lanes. The island is home to about 6,000 people, including many of the former British colony's expatriate workers.

_____

Follow Kelvin Chan at twitter.com/chanman

Source: http://news.yahoo.com/boat-sinks-off-hong-kong-collision-36-dead-013325176.html

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Gaming US Fiscal Reform by Mohamed A. El-Erian - Project Syndicate

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NEWPORT BEACH ? It sounded like a really clever idea: Use a very public and sizeable threat to get bickering politicians to collaborate and compromise. Well, it has not worked so far, and the already-sizeable stakes just got bigger.

No, I am not talking here about Europe?s debt crisis, decisive resolution of which still requires greater cooperation and shared responsibility, both within individual eurozone member states and between creditor and debtor countries. I am referring to the complex fiscal situation in the United States ? a fluid problem that has just been rendered more consequential by the recent warning from the ratings agency Moody?s that the US could lose its top credit rating next year if Congress fails to make progress on medium-term fiscal reforms.

Hobbled by the self-inflicted wounds of the debt-ceiling debacle in the summer of 2011 ? which undermined economic growth and job creation, and further damaged Americans? confidence in their political system ? the US Congress and President Barack Obama?s administration recognized the need for a measured and rational approach to fiscal reform. To increase the likelihood of this, they agreed on immediate spending cuts and tax increases that would automatically kick in (the ?fiscal cliff?) if agreement on a comprehensive set of fiscal reforms eluded them.

On paper, at least, this sizeable threat ? involving blunt fiscal contraction amounting to some 4% of GDP ? should have properly aligned incentives in Washington, DC. After all, no politician would wish to go down in history as being responsible for pushing the country back into recession at a time when unemployment is already too high, income and wealth inequalities are increasing, and a record number of Americans live in relative poverty.

Yet, so far, the threat has not worked. To understand why, we can appeal to game theory, which provides economists and others a powerful framework with which to explain the dynamics of both simple and complex interactions.

The objective of threatening a fiscal cliff was to force a ?cooperative outcome? on an increasingly ?non-cooperative game.? But, in the absence of a credible enforcer (and lacking sufficient mutual assurances), participants felt that they had more to gain from continuing their non-cooperative behavior.

Politicians on both sides of America?s political divide have generally felt that compromise would be viewed as a sign of weakness. Moreover, too many have made prior commitments ? for example, promising never to increase taxes ? that they find hard to break, especially ahead of elections that both sides deem to be of defining significance for the country?s future, reflected in the candidates? campaigns, which are getting nastier by the day.

The cost-benefit calculations will likely evolve after the election in November. At that point, the cost of being singled out as collaborating with members of the other side ? and thus the risk of being unseated by more extreme forces in one?s party ? may well decline. Moreover, since early September, the potential benefits of cooperation now include avoiding an embarrassing credit-rating downgrade next year if medium-term fiscal reform does not materialize.

I suspect that some will be quick to dismiss the consequences of a Moody?s downgrade. And it certainly is tempting to do so. After all, the global financial crisis badly damaged the credibility of ratings agencies as a whole. Moreover, one would be hard pressed to identify any meaningful hit to the US from the decision by another major agency, Standard & Poor?s, to downgrade America?s sovereign rating in August 2011.

On the contrary, rather than spiking higher following S&P?s unprecedented move, US market interest rates continued to fall, reaching record-low levels. This seemingly contradictory fall in financing costs reflected an abundance of foreign capital seeking to invest in the US, including money fleeing from Europe. The absence of any adverse impact on government finances may thus lead some to dismiss the impact of a potential Moody?s downgrade in 2013.

Yet, those of us who are exposed on a daily basis to the inner workings of financial markets would caution against too upbeat an attitude toward a second downgrade by a major ratings agency. Moreover, the potential impact certainly is not linear.

Owing to the way that investment contracts are written and guidelines specified, there is a meaningful difference between a single and multiple rating downgrades. Were Moody?s to follow S&P in stripping the US of its triple-A rating, the most likely outcome is that the universe of global investors who are both able and willing to increase their holdings of US government securities would shrink over time.

Fortunately for the US, the immediate adverse impact on borrowing costs would be alleviated, if not nullified, by investors? lack of readily available alternatives to US government bonds, as well as a Federal Reserve that has been buying large volumes of US Treasuries. But this is not a long-term risk worth taking.

Historically, it has taken countries many years of difficult fiscal-policy efforts to regain a triple-A status. And, while no one can be certain about where the limits lie, there are both theoretical and operational bounds to how many government bonds can (and should) be placed on the balance sheet of a modern, well-functioning central bank.

All of this suggests that, whether in the lame-duck congressional session following the elections or in the first few months of the new Congress, US politicians will likely dismantle the fiscal cliff. Based on an assessment of potential commonality among the political parties, such a compromise would limit the contractionary fiscal impact to some 1.5% of GDP.

Such a mini-bargain would go a long way toward reducing the risk of a serious US recession. But it would fall short of the type of fiscal reforms that would satisfy Moody?s. Such reforms require a grand bargain between America?s political parties, which in turn presupposes visionary leadership by both of them.

Reprinting material from this Web site without written consent from Project Syndicate is a violation of international copyright law. To secure permission, please contact us.

Source: http://www.project-syndicate.org/commentary/gaming-us-fiscal-reform-by-mohamed-a--el-erian

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Monday, October 1, 2012

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Apixaban superior to warfarin across range of patient risk scores, study finds

ScienceDaily (Oct. 2, 2012) ? A new anticoagulant called apixaban is superior to warfarin in preventing stroke with consistent effects across a wide range of stroke and bleeding risk in patients with atrial fibrillation, according to Duke University Medical Center researchers.

Their results, published online today in The Lancet, suggest that the current risk scoring systems for tailoring anticoagulation treatment to individual patients may be less relevant when using apixaban for patients with atrial fibrillation who have at least one risk factor for stroke.

"The benefits of apixaban are preserved regardless of the risk score used and regardless of the patient risk category," said Renato Lopes, M.D., a Duke cardiologist and the lead author of the study. Importantly, apixaban was safer than warfarin in the overall population and tended to cause less intracranial bleeding in those patients whose risk scores defined them as being at the highest risk of bleeding.

"With new oral anticoagulants, such as apixaban, we might not need risk scores to guide treatment decisions for stroke prevention in patients with atrial fibrillation. This may simplify how physicians make decisions and also improve patient care," Lopes said.

Practice guidelines have allowed use of either antithrombotic therapy with warfarin or with aspirin, which is less effective but has lower risk of bleeding, for patients with atrial fibrillation and one risk factor for stroke. Apixaban, with better prevention of stroke and lower risk of bleeding than warfarin, may remove aspirin as an attractive option for this group of patients.

Atrial fibrillation is a common abnormal heart rhythm that affects more than 2.6 million people in the United States. It occurs when the heart's electrical activity becomes disorganized, resulting in an irregular heartbeat with ineffective contraction of the upper chambers of the heart. The potential for blood clots to form, and one's risk for stroke, increases as a result.

Risk scores for bleeding and thromboembolism (blood clots) have been used to predict the risk of these events to guide use of warfarin, a vitamin K antagonist that is standard treatment to help prevent stroke and blood clots. Only about half of patients who could benefit from warfarin actually do because the drug has several limitations, including a requirement for regular monitoring and increased bleeding risk such as intracranial hemorrhage.

Apixaban is an oral direct factor Xa inhibitor that has already been shown to be safer and more effective than warfarin for patients with atrial fibrillation. Last year, Duke researchers presented the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial at the European Society of Cardiology. It showed apixaban resulted in an additional 21 percent relative reduction in stroke or systemic embolism when compared to warfarin, a 31 percent relative reduction in major bleeding, and an 11 percent relative reduction in overall mortality.

The analysis published in The Lancet used the ARISTOTLE data to assess safety and efficacy of apixaban versus warfarin in 18,201 patients based on the most popular risk assessment scores. CHADS2, CHA2DS2VASc, and HAS-BLED are used to estimate risk of stroke and bleeding in patients with atrial fibrillation and help guide warfarin treatment decisions.

"Risk stratification has been a key element in identifying patients at risk for stroke and bleeding and in helping to guide antithrombotic treatment for patients with atrial fibrillation," Lopes said. "However, most of patients at high risk for stroke are also at high risk for bleeding. This makes the treatment of these patients a challenge in clinical practice.

"Our study shows that irrespective of the risk of stroke or bleeding, apixaban is more effective and safer than warfarin across all patients with atrial fibrillation and at least one additional risk factor for stroke," Lopes said. "Thus, the current risk scores used in clinical practice for patients with atrial fibrillation may play less of a role in decision-making because we now have more efficacious and safer drugs."

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The above story is reprinted from materials provided by Duke University Medical Center.

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Journal Reference:

  1. Lopes et al. Efficacy and safety of apixaban compared with warfarin according to patient risk of stroke and of bleeding in atrial fibrillation: a secondary analysis of a randomised controlled trial. The Lancet, 2012; DOI: 10.1016/S0140-6736(12)60986-6

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/fHFhy8grVLQ/121001191533.htm

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Stem cells improve visual function in blind mice

ScienceDaily (Oct. 1, 2012) ? An experimental treatment for blindness, developed from a patient's skin cells, improved the vision of blind mice in a study conducted by Columbia ophthalmologists and stem cell researchers.

The findings suggest that induced pluripotent stem (iPS) cells -- which are derived from adult human skin cells but have embryonic properties -- could soon be used to restore vision in people with macular degeneration and other diseases that affect the eye's retina.

"With eye diseases, I think we're getting close to a scenario where a patient's own skin cells are used to replace retina cells destroyed by disease or degeneration," says the study's principal investigator, Stephen Tsang, MD, PhD, associate professor of ophthalmology and pathology & cell biology. "It's often said that iPS transplantation will be important in the practice of medicine in some distant future, but our paper suggests the future is almost here."

The advent of human iPS cells in 2007 was greeted with excitement from scientists who hailed the development as a way to avoid the ethical complications of embryonic stem cells and create patient-specific stem cells. Like embryonic stem cells, iPS cells can develop into any type of cell. Thousands of different iPS cell lines from patients and healthy donors have been created in the last few years, but they are almost always used in research or drug screening.

No iPS cells have been transplanted into people, but many ophthalmologists say the eye is the ideal testing ground for iPS therapies.

"The eye is a transparent and accessible part of the central nervous system, and that's a big advantage. We can put cells into the eye and monitor them every day with routine non-invasive clinical exams," Tsang says. "And in the event of serious complications, removing the eye is not a life-threatening event."

In Tsang's new preclinical iPS study, human iPS cells -- derived from the skin cells of a 53-year-old donor -- were first transformed with a cocktail of growth factors into cells in the retina that lie underneath the eye's light-sensing cells.

The primary job of the retina cells is to nourish the light-sensing cells and protect the fragile cells from excess light, heat, and cellular debris. If the retina cells die -- which happens in macular degeneration and retinitis pigmentosa -- the photoreceptor cells degenerate and the patient loses vision. Macular degeneration is a leading cause of vision loss in the elderly, and it is estimated that 30 percent of people will have some form of macular degeneration by age 75. Macular degeneration currently affects 7 million Americans and its incidence is expected to double by 2020.

In their study, the researchers injected the iPS-derived retina cells into the right eyes of 34 mice that had a genetic mutation that caused their retina cells to degenerate.

In many animals, the human cells assimilated into mouse retina without disruption and functioned as normal retina cells well into the animals' old age. Control mice that got injections of saline or inactive cells showed no improvement in retina tests.

"Our findings provide the first evidence of life-long neuronal recovery in a preclinical model of retinal degeneration, using stem cell transplant, with vision improvement persisting through the lifespan," Tsang says. "And importantly, we saw no tumors in any of the mice, which should allay one of the biggest fears people have about stem cell transplants: that they will generate tumors."

Tsang hopes to begin a clinical trial for macular degeneration patients in the next three years, after more preclinical testing in animal models.

Already a similar trial -- testing retina cells derived from embryonic stem cells -- has seen encouraging preliminary results. A paper from this study, published earlier this year, reported that the stem cells are safe and have potential to improve the vision of two patients with macular degeneration.

"These results are encouraging, but iPS cells could be a more attractive option than embryonic stem cells," Tsang says, "because patients may not need drugs to prevent rejection of the transplanted cells."

Regardless of which cell works better, the prospect of stem cell transplants may mean many people with macular degeneration may never lose their vision.

"We have a good idea which patients will eventually lose their vision. In the early stages of macular degeneration we can tell by looking in the eye, and new genetic tests can now predict vision loss with 70 percent accuracy even before those signs emerge," Tsang says. "If the therapy is safe, we could intervene very early to prevent much vision loss."

The study was published online in advance of print in the journal Molecular Medicine. The research was supported by NIH grants 5P30CA013696, P30EY019007, and R01EY018213; the Schneeweiss Stem Cell Fund, and the Foundation Fighting Blindness.

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The above story is reprinted from materials provided by Columbia University Medical Center. The original article was written by Susan Conova.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/ttXml6yDcNc/121001141127.htm

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